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Wednesday, April 22, 2026
Phoenix, AZ — April 21, 2026
The Arizona Diamondbacks came into Tuesday night riding momentum, winning eight of their last eleven games and four straight series. But in your first live coverage of the 2026 season, the Chicago White Sox wasted no time flipping the script—delivering a dominant 11-5 win at Chase Field.
What started as a promising night quickly unraveled, as Chicago’s explosive offense overwhelmed Arizona from the opening inning and never let up.
Game Turns in the First Inning
Before Merrill Kelly could settle in, the White Sox loaded the bases with no outs and capitalized immediately. A two-run double from Colson Montgomery opened the scoring, followed by a sacrifice fly and an RBI triple to make it 4-0 before Arizona could record three outs.
The Diamondbacks had a chance to answer in the bottom half of the inning, putting runners in scoring position, but a costly out at home plate ended the threat. That missed opportunity loomed large as the game progressed.
Power Surge Puts Game Away Early
Chicago didn’t just build a lead—they buried Arizona with it in the second inning.
Munetaka Murakami launched a 426-foot home run to right field, followed immediately by back-to-back homers from Miguel Vargas and Colson Montgomery. Three straight swings turned the game into a 7-0 rout and silenced the Chase Field crowd early.
From that moment on, Arizona was playing uphill.
Kelly Tagged in Rare Struggle
Merrill Kelly entered the game as one of Arizona’s most reliable arms, but this outing was far from his best. He lasted just 4.1 innings, allowing 10 hits and 8 earned runs while giving up three home runs.
For a team built on pitching consistency early in the season, this was an uncharacteristic breakdown—and one they couldn’t recover from.
Late Push Shows Fight
Despite the lopsided score, the Diamondbacks didn’t fold.
Alek Thomas provided a spark with his first home run of the season in the fifth inning, and Geraldo Perdomo added a triple as Arizona chipped away at the deficit. The biggest moment came in the ninth, when Ildemaro Vargas launched a three-run homer to right field.
That blast not only cut into the lead but extended Vargas’ remarkable hitting streak to 16 games to start the season—continuing one of the hottest runs in Major League Baseball.
Strange Bounce in the Ninth
The night also featured a controversial moment that added to Arizona’s frustration. In the top of the ninth, Sam Antonacci recorded an inside-the-park home run on a play that appeared to involve possible interference near the foul line.
With no call made on the field, the play stood, pushing Chicago’s lead to 10-2 at the time and removing any lingering doubt about the outcome.
Missed Chances Cost Arizona
While Chicago’s offense stole the spotlight, Arizona’s inability to capitalize in key moments played a major role in the loss.
They stranded runners in critical situations early and again in the eighth inning when they put the first two batters on base but failed to score. Against a team swinging the bats like Chicago, those missed opportunities proved costly.
A Milestone in the Loss
One bright spot came quietly amid the chaos. Nolan Arenado crossed the plate for the 1,000th time in his career, reaching a significant milestone even in defeat.
Looking Ahead
Interestingly, this loss fits a familiar pattern for Arizona. The Diamondbacks have now dropped the first game in nearly every series this season—but have still gone on to win most of them.
They’ll look to do it again with their top arms taking the mound over the next two games. Eduardo Rodriguez is set to start Wednesday night, followed by Michael Soroka in Thursday’s series finale.
If Arizona is going to bounce back, it starts with pitching—and avoiding another early deficit.
Final Thoughts
This one wasn’t just a loss—it was a reminder.
You can’t fall behind 4-0 in the first inning…
You can’t give up three straight home runs…
And you can’t waste scoring chances against a team that’s swinging like that.
The good news? This team has shown resilience all season.
Now we find out if that trend continues.
Don’t miss The S3 Podcast with Jeff Demers (JD) and Marnie Tisdale (Lady M), streaming every Friday at 4PM PST (schedule may vary based on live press coverage) on our YouTube channel. Catch the replay anytime on your favorite podcast platform!

Sports Director for Sports Media X/Coach Jeff Demers
"For the past ten years, I've been deeply immersed in the world of Valley sports. I wear many hats, serving not only as a Sports Director but also as a journalist, photographer, podcaster, and the creator of the "Sports Media X" program, dedicated to building sports media brands. Beyond my sports endeavors, I'm a fervent entrepreneur and a business coach, specializing in marketing and sales for small businesses."

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